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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
S7971-01E3.100 | 100 µl | - | - |
3 - 19 business days* |
834.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Stat3 is a key signaling molecule for many cytokines and growth-factor receptors and is required... more
Product information "Anti-phospho-STAT3 (Tyr705) (Signal Transducer and Activator of Transcription 3, Acute-phase Respons"
Stat3 is a key signaling molecule for many cytokines and growth-factor receptors and is required for murine fetal development. Additionally, Stat3 is constitutively activated in a number of human tumors and possesses oncogenic potential and anti-apoptotic activities. Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation and DNA binding. Transcriptional activation seems to be regulated by phosphorylation at Ser727 via the MAPK or mTOR pathway. Stat3 isoform expression appears to reflect biological function: the relative expression levels of Stat3a (86kD) and Stat3b (79kD) depend on cell type, ligand exposure or maturation stage of the cells. It is notable that Stat3b lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain., , Applications:, Suitable for use in Western Blot, Immunohistochemistry, Immunoprecipitation, Immunofluoresence, Flow Cytometry, and Chromatin Immunoprecipitation (ChIP). Other applications have not been tested. , Recommended Dilutions: Western Blot: 1:2000 Incubate with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking overnight. , Immunoprecipitation: 1:100, Immunohistochemistry (Paraffin): 1:400. Antigen retrieval by heating in EDTA, pH 8 is required., Immunohistochemistry (frozen): 1:200, Fixative: 3% formaldehyde, Immunofluorescence (IF-IC): 1:100. Methanol permeabilization required, Flow Cytometry: 1:200, ChIP: 1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | Anti-phospho-Acute-phase response factor, Anti-phospho-Signal transducer and activator of transcription 3 |
Supplier: | United States Biological |
Supplier-Nr: | S7971-01E3 |
Properties
Application: | FC, IF, IHC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | 7H65(D3A7) |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, monkey, mouse, rat |
Immunogen: | Synthetic phosphopeptide (KLH-coupled) corresponding to residues surrounding Tyr705 of mouse Stat3. |
Format: | Supernatant |
Database Information
KEGG ID : | K04692 | Matching products |
UniProt ID : | P40763 | Matching products |
Gene ID | GeneID 6774 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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