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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-4110-100 | 100 tests | - |
3 - 11 business days* |
658.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Stat1 mediates the cellular response to IFN alpha, IFNB, and IFNg for the regulation of cell... more
Product information "Anti-phospho-Stat1 (Tyr701) (Clone: 3E6)rabbit mAb SureLight488 conjugate"
Stat1 mediates the cellular response to IFN alpha, IFNB, and IFNg for the regulation of cell growth and the defense against viral and immune challenges. The Jak-Stat pathway plays a central role in the IFNg response, where Stat1 phosphorylation on Tyr701 causes homodimerization through its SH2 domain, translocation to the nucleus, and binding to gamma-activated sequence (GAS) elements. Early in the activation sequence, Stat1 is also phosphorylated at Ser727 through a mechanism involving PI3 kinase and Akt. Stat1 has been found to correlate with increased resistance to chemotherapeutic drugs. However, Stat1 activation of the immune system helps suppress tumor growth, and multiple melanomas and squamous-cell carcinomas have been known to downregulate Stat1 expression to evade immune surveillance.
Keywords: | Anti-phospho-STAT1, Anti-phospho-Transcription factor ISGF-3 components p91/p84, Anti-phospho-Signal transducer and activator of transcription 1-alpha/beta |
Supplier: | Abeomics |
Supplier-Nr: | 12-4110 |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | Stat1Y701-3E6 |
Conjugate: | SureLight |
Host: | Rabbit |
Species reactivity: | human, mouse |
Database Information
KEGG ID : | K11220 | Matching products |
UniProt ID : | P42224 | Matching products |
Gene ID | GeneID 6772 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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