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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
R1660-26G.10 | 10 blots | - | - |
3 - 19 business days* |
909.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by... more
Product information "Anti-phospho-Retinoblastoma (Thr821) (Rb)"
Rb is a tumor suppressor gene which functions as a negative regulator of the cell cycle by interacting with transcription factors including E2F-1, PU.1, ATF-2, UBF, Elf-1 and c-Abl. This ability to alter transcription is regulated by phosphorylation catalyzed by the cyclin-dependent protein kinases (cdks). Rb contains at least 16 consensus sequences for cdk phosphorylation, but the significance of all of these sites is unclear. Rb threonine 821 phosphorylation (catalyzed by cdk2) disrupts interaction with proteins containing the sequence LxCxE. Phosphorylation of this site (in additional to serines 780, 807 and 811) also disrupts binding to E2F. Applications: Suitable for use in Western Blot. Other applications have not been tested. Recommended Dilutions: Western Blot: 1:1000 , Optimal dilutions should be determined by the researcher. Positive Control: Jurkat cells in high growth phase. , Storage and Stability:, May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-phospho-Rb, Anti-phospho-RB1, Anti-phospho-pRb, Anti-phospho-pp110, Anti-phospho-p105-Rb, Anti-phospho-Retinoblastoma-associated protein |
Supplier: | United States Biological |
Supplier-Nr: | R1660-26G |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic phosphopeptide derived from a region of human Rb that contains threonine 821. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06618 | Matching products |
UniProt ID : | P06400 | Matching products |
Gene ID | GeneID 5925 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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