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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-4341-200 | 200 µl | - |
3 - 11 business days* |
921.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein Kinase (PKC) is a 12 member family of serine/threonine kinases termed conventional or... more
Product information "Anti-phospho-PKC (pan) (Clone: gamma Thr514) (Clone: PF4) rabbit mAb"
Protein Kinase (PKC) is a 12 member family of serine/threonine kinases termed conventional or classical(a b,g), novel (d ,e ,andq ), atypical (z ,l) and PKN and PKC-related (PKN1, PKN2 and PKN3) playing significant role in several signaling processes involved in physiological and pathological setting (1). PKC activation translates into gene expression modulation, cell division, migration, proliferation, differentiation, and cell survival and apoptosis (2).PKC members are classified based on their distinct cofactor requirements and the extent of homology between their regulatory elements (3,4). PKCalpha,beta I,beta II, andgamma constitute the conventional PKC isoforms, characterized by the presence of two cysteine-rich zinc finger domains, C1a and C1b (5,6) which bind to diacylglycerol (DAG) and phosphatidylserine (PS) (7). In addition, PKC contains a C2 domain, responsible for binding anionic phospholipids like phosphatidylinositol bisphosphate (PIP2) in a Ca2+-dependent manner (8,9). The atypical PKC, PKCzandlshare ATP-binding domain and the catalytic domain with PKC. They contain a single C1 domain that lacks residues necessary for binding DAG (10). Association of PKCg to the membrane enables a conformation that permits phosphoinositide-dependent protein kinase1 (PDK-1) (11) to bind and phosphorylate a site in the activation loop, Thr514. (12,13). Thr514 phosphorylation leads to a conformation change enabling phosphorylation of at two carboxyl-terminal sites namely, the turn motif and hydrophobic motif, as a result of which the fully phosphorylated conventional PKC is released from the membrane, and positioned in the cytoplasm as an inactive form (14,15). Binding of Ca 2+induces low-affinity interaction with the membrane, whereas the membrane imbedded cofactor DAG to PKC results in high-affinity interaction of PKC with the membrane (16).
Keywords: | Anti-phospho-PKCG, Anti-phospho-PRKCG, Anti-phospho-PKC-gamma, EC=2.7.11.13, Anti-phospho-Protein kinase C gamma type |
Supplier: | Abeomics |
Supplier-Nr: | 12-4341 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | PKCgT514-PF4 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Database Information
KEGG ID : | K19663 | Matching products |
UniProt ID : | P05129 | Matching products |
Gene ID | GeneID 5582 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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