Anti-phospho-p21Cip1 (Thr145)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG51698.50	50 µl		-	-	6 - 14 business days*		436.00€
ARG51698.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: May be the important intermediate by which p53/TP53 mediates its role as an... more

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Product information "Anti-phospho-p21Cip1 (Thr145)"

Protein function: May be the important intermediate by which p53/TP53 mediates its role as an inhibitor of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity, preventing phosphorylation of critical cyclin- dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D- CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios, inhibits the kinase activity of the cyclin D-CDK4 complex. [The UniProt Consortium]

Keywords:	Anti-phospho-p21, Anti-phospho-CAP20, Anti-phospho-MDA-6, Anti-phospho-CDKN1A, Anti-phospho-CDK-interacting protein 1, Anti-phospho-Cyclin-dependent kinase inhibitor 1, Anti-phospho-Melanoma differentiation-associated protein 6
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG51698

Properties

Application:	IHC (paraffin)
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Peptide sequence around phosphorylation site of threonine 145 (R-Q-T(p)-S-M) derived from Human p21Cip1
Format:	Affinity Purified