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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
M2352-10D.100 | 100 µl | - | - |
3 - 19 business days* |
819.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Erk (Extracellular signal-Related Kinase) is a family of two, highly homologous proteins denoted... more
Product information "Anti-phospho-MAP Kinase p44/42, (Thr185/Tyr187) (MAPK, Erk1/2, Extracellular Signal Regulated Kinase"
Erk (Extracellular signal-Related Kinase) is a family of two, highly homologous proteins denoted as Erk1 (p44, MAPK3) and Erk2 (p42, MAPK1) that both function in the same pathway. The two proteins are often referred to collectively as ERK1/2 or p44/p42 MAP kinase. The Erk pathway is considered the classical, canonical MAPK (Mitogen-Activated Protein Kinase) signaling pathway. It is an evolutionarily conserved pathway that controls and is a critical regulator the growth and survival through the promotion of cell proliferation and the prevention of apoptosis. Erk is involved in the control of many fundamental cellular processes including cell proliferation, survival, differentiation, apoptosis, motility and metabolism. Erk is activated by growth factor stimulation of receptor tyrosine kinases (RTKs) and/or integrin stimulation. This activates the Ras-Raf-MEK,-Erk pathway that results in MEK, a dual kinase (a Ser/Thr and a Tyr kinase), phosphorylation and activation of ERK1/2 (p44/044) on the TxY motif (Thr202/Tyr204 and Thr185/Tyr187 for Erk1 and Erk2, respectively). Applications: Suitable for use in Western Blot and Multiplexing., Other applications not tested. Recommended Dilution: Western Blot: 1:5000, Optimal dilutions to be determined by the researcher. Positive Control: RIPA cell lysate from NGF stimulated PC-12 cells. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=2.7.11.24, Anti-phospho-ERT2, Anti-phospho-ERK-1, Anti-phospho-MAPK3, Anti-phospho-MAPK 1, Anti-phospho-MAPK 3, Anti-phospho-p44-ERK1, Anti-phospho-p44-MAPK, Anti-phospho-MAP kinase 3, Anti-phospho-MAP kinase 1, Anti-phospho-MAP kinase isoform p44 |
Supplier: | United States Biological |
Supplier-Nr: | M2352-10D |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 10F648 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to amino acids surrounding the pTEpY motif of human phospho-MAP Kinase 1/2 (Erk1/2), in which the Thr and Tyr residues are phosphorylated (KLH). The immunizing sequence is highly conserved among species. |
Format: | Supernatant |
Database Information
KEGG ID : | K04371 | Matching products |
UniProt ID : | P27361 | Matching products |
Gene ID | GeneID 5595 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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