Anti-phospho--LKB1 (STK11,serine/threonine kinase 11,PJS, Renal carcinoma antigen NY-REN-19, Serine/

LKB1 (also STK11 and JBS) is a 55kD member of the CAMK Ser/Thr protein kinase , family. It is ubiquitously expressed, and considered to be a tumor suppressor. LKB1 is , both nuclear and cytoplasmic, and appears to contribute to cell polarization, G1 cell cycle , arrest and Wnt signaling. It is known to complex with STRAD and CAB39/MO25, and , phosphorylate PTEN plus p53. Human LKB1 is 433 amino acids (aa) in length. It contains , a protein kinase domain (aa 49-309) and a prenylation motif (CysLysGlnGln) over , aa 430-433. Phosphorylation on Ser428 promotes the ability of LKB1 to suppress G361 , cell growth. There are two potential isoforms of LKB1. One shows a nine aa insertion after , Tyr126, while another shows a 34 aa substitution for aa 371-433. Over aa 242-433, , human and mouse LKB1 are identical in aa sequence. Applications: Suitable for Western Blot. Other applications not tested. Storage: Lyophilized samples are stable for twelve months from date of receipt when stored , at -20°C to -70°C. Upon reconstitution, the antibody can be stored at 2°-8°C for , 1 month without detectable loss of activity. Reconstituted antibody can also be aliquotted , and stored frozen at -20°C to -70°C in a manual defrost freezer for six months without , detectable loss of activity. Avoid repeated freeze-thaw cycles.