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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-12-4311-200 | 200 µl | - |
3 - 11 business days* |
921.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
HS1 is expressed in lymphoid and hematopoietic cells, and is heavily post-translationally... more
Product information "Anti-phospho-HS1 (Tyr397) (Clone: F12) rabbit mAb"
HS1 is expressed in lymphoid and hematopoietic cells, and is heavily post-translationally modified. HS1 deficient mouse models have demonstrated the protein's role in receptor-mediated apoptosis and proliferation. HS1 is phosphorylated at Tyr378 and Tyr397 by the kinase Syk, providing a high-affinity binding site for SH2 domains from the Src family. Following this interaction, HS1 is then phosphorylated at Tyr222 by c-Fgr, Lyn, and Fyn kinases. HS1 plays an important role in T cell signaling, where HS1 phosphorylation recruits and activates Vav1 at the immune synapse. As a homolog of the actin binding protein cortactin, HS1 has been shown to mediate neutrophil chemotaxis through phosphorylation of tyrosines 222, 378, and 397.
Keywords: | Anti-phospho-p75, Anti-phospho-HS1, Anti-phospho-HCLS1, Anti-phospho-LckBP1, Anti-phospho-Hematopoietic lineage cell-specific protein, Anti-phospho-Hematopoietic cell-specific LYN substrate 1 |
Supplier: | Abeomics |
Supplier-Nr: | 12-4311 |
Properties
Application: | FC, WB |
Antibody Type: | Monoclonal |
Clone: | HS1Y397-F12 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Database Information
KEGG ID : | K06106 | Matching products |
UniProt ID : | P14317 | Matching products |
Gene ID | GeneID 3059 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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