Anti-phospho-Histone H3 (Thr11)

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG51846.50	50 µl		-	-	6 - 14 business days*		436.00€
ARG51846.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Variant histone H3 which replaces conventional H3 in a wide range of... more

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Product information "Anti-phospho-Histone H3 (Thr11)"

Protein function: Variant histone H3 which replaces conventional H3 in a wide range of nucleosomes in active genes. Constitutes the predominant form of histone H3 in non-dividing cells and is incorporated into chromatin independently of DNA synthesis. Deposited at sites of nucleosomal displacement throughout transcribed genes, suggesting that it represents an epigenetic imprint of transcriptionally active chromatin. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. [The UniProt Consortium]

Keywords:	Anti-phospho-Histone H3.3
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG51846

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	rat
Immunogen:	Peptide sequence around phosphorylation site of threonine 11(K-S-T(p)-G-G) derived from Human Histone H3
Format:	Antigen Affinity Purified