Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay35902-100 | 100 µl | - | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
ERK1 and ERK2, also known as ERK1/2, are serine/threonine protein kinases and essential... more
Product information "Anti-ERK1/2 (Phospho-Thr202/Tyr204) Rabbit Monoclonal Antibody (Clone RM451)"
ERK1 and ERK2, also known as ERK1/2, are serine/threonine protein kinases and essential components of the MAP kinase signaling cascade. They share 84% sequence homology and are each composed of a glycine-rich loop, hinge region, and protein kinase domain containing a catalytic HRD motif, activation segment, and kinase insert domain. ERK1/2 are ubiquitously expressed though ERK2 is expressed at higher levels than ERK1 and is predominant in the brain and hematopoietic cells. Both isoforms localize to the cytosol anchored to MEK1/2. Upon extracellular stimulation with mitogens, growth factors, or cytokines, the MAP kinase signaling cascade is initiated and terminates with dual phosphorylation of ERK1 and ERK2 in the activation segment's activation lip at Thr202/Tyr204 or Thr185/Tyr187, respectively, by MEK1/2. Upon activation, ERK1/2 phosphorylate and activate substrates in the cytosol or various subcellular compartments, including the nucleus where they induce activation of transcription factors involved in cell proliferation, differentiation, and the stress response. Misregulation of the MAP kinase cascade drives development of various cancers. Cayman's ERK1/2 (Phospho-Thr202/Tyr204) Rabbit Monoclonal Antibody (Clone RM451) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Synonyms: p44/p42 MAPK, MAPK3/MAPK1. Immunogen: Peptide corresponding to human ERK1/2 (phospho-Thr202/Tyr204). Clone Designation: RM451. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) ERK1/2 (phospho-Thr202/Tyr204), (-) ERK1/2 without phosphorylation at Thr202/Tyr204.
Keywords: | Anti-phospho-ERT1, Anti-phospho-ERK2, Anti-phospho-MAPK1, Anti-phospho-ERK-2, Anti-phospho-MAPK 2, Anti-phospho-MAPK 1, Anti-phospho-p42-MAPK, EC=2.7.11.24, Anti-phospho-MAP kinase 1, Anti-phospho-MAP kinase 2, Anti-phospho-MAP kinase isoform p42 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 35902 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM451 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Peptide corresponding to human ERK1/2 (phospho-Thr202/Tyr204) |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04371 | Matching products |
UniProt ID : | P28482 | Matching products |
Gene ID | GeneID 5594 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed