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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay35901-100 | 100 µl | - | - |
6 - 10 business days* |
480.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Epidermal growth factor receptor (EGFR), also known as HER1 and ErbB-1, is a cell surface... more
Product information "Anti-EGFR (Phospho-Tyr1068) (Clone RM443)"
Epidermal growth factor receptor (EGFR), also known as HER1 and ErbB-1, is a cell surface receptor and member of the EGF family of receptor tyrosine kinases with roles in cell proliferation, differentiation, and survival. It is a transmembrane receptor composed of an intracellular tyrosine kinase domain, a transmembrane lipophilic segment, and an extracellular domain that is expressed in epithelial, mesenchymal, and neuronal tissues. Under unstimulated conditions, EGFR is an auto-inhibited monomer in the plasma membrane. Upon canonical ligand binding, EGFR undergoes homodimerization or heterodimerization with HER2, HER3, or HER4, which induces a conformational change in the cytoplasmic domain that facilitates autophosphorylation and intracellular signaling. EGFR contains five C-terminal autophosphorylation sites, namely tyrosine 1068 (Tyr1068), Tyr1148, Tyr1173, Tyr1086, and Tyr992. EGFR (phospho-Tyr1068) is associated with prolonged progression-free survival in patients with non-small cell lung cancer (NSCLC). Cayman's EGFR (Phospho-Tyr1068) Rabbit Monoclonal Antibody can be used for Western blot (WB).Synonyms: Epidermal Growth Factor Receptor, ErbB-1, Erb-B2 Receptor Tyrosine Kinase 1, HER1. Immunogen: A phospho-peptide corresponding to human phospho-EGFR. Clone Designation: RM443. Formulation: (Request formulation change), 100 µl of protein A-affinity purified monoclonal antibody. Storage Buffer: PBS with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: WB. Cross Reactivity: (+) EGFR (Phospho-Tyr1068), (-) EGFR without phosphorylation at Tyr1068.
Keywords: | Anti-phospho-ERBB, EC=2.7.10.1, Anti-phospho-Proto-oncogene c-ErbB-1, Anti-phospho-Epidermal growth factor receptor, Anti-phospho-Receptor tyrosine-protein kinase erbB-1 |
Supplier: | Cayman Chemical |
Supplier-Nr: | 35901 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | RM443 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Phospho-peptide corresponding to human phospho-EGFR |
Format: | Affinity Purified |
Database Information
KEGG ID : | K04361 | Matching products |
UniProt ID : | P00533 | Matching products |
Gene ID | GeneID 1956 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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