886 products were found matching "K04361"!

Erlotinib is an EGFR inhibitor (Ki = 2.7 nM). It is greater than 1,000-fold selective for EGFR over Src and Abl at 0.1 µM. Erlotinib induces caspase-3 and -7 activity in NCI H358 non-small cell lung cancer (NSCLC) cells when used at a concentration of 1 µM. Erlotinib (25 mg/kg) reduces EGF-induced EGFR...

STX-721 is an irreversible inhibitor of EGFR with an exon 20 insertion (ex20ins) mutation. It selectively inhibits the proliferation of Ba/F3 cells expressing EGFR exon20 A769_V770 insASV and EGFR exon20 D770_N771 insSVD (IC50s = 5. and 5. nM, respectively) over those expressing wild-type EGFR (IC50 = 127. nM)....

Befotertinib is an inhibitor of mutant EGFRs. It selectively inhibits EGFRL858R, EGFRE709K, EGFRG719A, and EGFRL861Q (IC50s = 0. 14, 1. and 13 nM, respectively), as well as EGFR containing an exon 19 deletion and EGFR containing an exon 18 deletion (IC50s = 0. and 24 nM, respectively), over wild-type EGFR (IC50 =...

BMS 690514 is a pan-inhibitor of HER and VEGFR family kinases (IC50s = 5, 19, 60, 50, 50, and 25 nM for EGFR, HER2, HER4, VEGFR1, VEGFR2, and VEGFR3, respectively). It is selective for these kinases over 11 additional kinases but also inhibits FMS-related tyrosine kinase 3 (FLT3), calcium/calmodulin-dependent...

Oritinib is an inhibitor of mutant EGFR. It selectively inhibits EGFRL858R, EGFRL858R/T790M, EGFRDelta746-750, and EGFRDelta746-750/T790M (IC50s = 0. 0. 1. and 0. nM, respectively) over wild-type EGFR (IC50 = 18 nM). In vivo, oritinib (2. 5, and 15 mg/kg) inhibits tumor growth in PC-9 and H1975 mouse xenograft...

Sevabertinib is a dual inhibitor of wild-type and exon 20 insertion (ex20ins) mutation-containing EGFR and HER2 (IC50s = 98%. Formulation (Request formulation change): A solid. Solubility: DMSO: Soluble: >10 mg/ml Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES:...

An inhibitor of mutant EGFR, selective for EGFRL858R/T790M, EGFRT790M, and EGFR containing an exon 19 deletion (IC50s = 0.3, 0.5, and 0.5 nM, respectively) over wild-type EGFR (IC50 = 6 nM) and a panel of 258 kinases at 100 nM, inhibits BTK and Itk (IC50s = 2.1 and 0.4 nM, respectively), selectively inhibits the...

A dimeric tyrphostin EGFR inhibitor (IC50 = 0.4 µM), selective for EGFR over the Bcr-Abl fusion proteins p210 and p185 and wild-type c-Abl (IC50s = 44, >100, and >100 µM, respectively, for the human proteins), inhibits EGFR autophosphorylation (IC50 = 3.3 µM), inhibits EGF-dependent proliferation of HER-14...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. The epidermal growth factor receptor (EGFR, ErbB-1, HER1 in humans) is the cell-surface receptor for members of the epidermal growth factor family (EGF-family) of extracellular protein ligands. It is a member of the ErbB family of receptors, a subfamily of four...

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA. Phospho-EGFR (Tyr845) antibody detects epidermal growth factor receptor (EGFR) phosphorylated at tyrosine 845, a modification within the activation loop of the kinase domain. EGFR is a receptor...

Epertinib is an inhibitor of EGFR, HER2, and HER4 (IC50s = 1.48, 7.15, and 2.49 nM, respectively). It is selective for these kinases over VEGFR2, insulin-like growth factor 1 receptor (IGF-1R), c-Src, KIT, and PDGFRbeta (IC50s = >10,000 nM for all). Epertinib inhibits EGFR and HER2 autophosphorylation in NCI N87...

DBPR112 is an inhibitor of EGFR and dual-mutant EGFRL858R/T790M (IC50s = 15 and 48 nM, respectively). It is selective for these kinases over 384 other kinases but does inhibit 11 additional kinases, including JAK3, Blk, and bone marrow tyrosine kinase on chromosome X (BMX), at 10,000 nM. DBPR112 reduces the...