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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay34123-300 | 300 µg | - |
6 - 10 business days* |
488.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
alpha-Enolase, also known as enolase-1, is a glycolytic enzyme that catalyzes the conversion of... more
Product information "Anti-Citrullinated a-Enolase (Clone 4A7)"
alpha-Enolase, also known as enolase-1, is a glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate. It is ubiquitously expressed in human tissues, including liver, spleen, kidney, and brain. In cells, alpha-enolase is primarily localized to the cytoplasm, however, an alternatively translated form localizes to the nucleus and lacks glycolytic enzyme activity. alpha-Enolase functions as a cell surface receptor for plasminogen on pathogens and activated immune cells, as an oxidative stress protein in endothelial cells, and as a chromatin binding partner to facilitate transcription. It is an autoantigen in asthma, Hashimoto's encephalopathy, and rheumatoid arthritis, and has been found in the serum of pediatric patients with juvenile idiopathic arthritis. alpha-Enolase is also subject to citrullination by peptidyl arginine deiminases (PADs) and citrullinated alpha-enolase has been found in the synovial fluid of rheumatoid arthritis patients. Cayman's Citrullinated alpha-Enolase Monoclonal Antibody (Clone 4A7) can be used for ELISA and Western blot applications. The antibody recognizes citrullinated alpha-enolase at approximately 47 kDa from human samples.Synonyms: 2-phospho-D-Glycerate Hydrolyase, ENO1, Enolase-1, Non-neural Enolase, Phosphopyruvate Hydratase, Plasminogen-binding Protein. Immunogen: A synthetic citrullinated peptide corresponding to the N-terminal region of human alpha-enolase. Clone Designation: 4A7. MW: ~47 kDa. Formulation: (Request formulation change), 300 µg of protein G-affinity purified monoclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: ELISA, WB. Cross Reactivity: (+) Citrullinated alpha-enolase, (+) Citrullinated vimentin, (-) Non-citrullinated alpha-enolase, (-) Citrullinated HSP90, (-) Citrullinated fibrinogen, (-) Citrullinated beta-catenin, (-) Citrullinated glucose-6-phosphate isomerase. UniProt Accession #: P06733.
Keywords: | Anti-NNE, Anti-NNE, Anti-ENO1, Anti-MBP-1, Anti-MPB-1, Anti-MBP-1, Anti-MPB-1, Anti-ENO1L1, Anti-Enolase 1, Anti-Enolase 1, Anti-Alpha-enolase, Anti-Alpha-enolase, Anti-Non-neural enolase, Anti-Non-neural enolase, Anti-Phosphopyruvate hydratase, Anti-Phos |
Supplier: | Cayman Chemical |
Supplier-Nr: | 34123 |
Properties
Application: | ELISA, WB |
Antibody Type: | Monoclonal |
Conjugate: | No |
Host: | Mouse |
Immunogen: | A synthetic citrullinated peptide corresponding to the N-terminal region of human ?-enolase |
Format: | Purified |
Database Information
KEGG ID : | K01689 | Matching products |
UniProt ID : | P06733 | Matching products |
Gene ID | GeneID 2023 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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