Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay26742-500 | 500 µl | - |
6 - 10 business days* |
649.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Citrullinated myelin basic protein (citMBP) is a citrullinated form of MBP, a protein that is... more
Product information "Anti-citrulinated-Citrullinated Myelin Basic Protein"
Citrullinated myelin basic protein (citMBP) is a citrullinated form of MBP, a protein that is integral to myelin stability in the CNS. MBP contains 19 arginine residues that can be citrullinated by peptidylarginine deiminases (PADs), decreasing the positive charge of MBP. The loss of positive charge disrupts MBP-lipid interactions, leading to myelin destabilization and loss and increases its susceptibility for degradation. MBP is degraded by the myelin-associated protease cathepsin D, which leads to exposure and release of immunodominant epitopes. The percentage of MBP that is citrullinated is increased in the postmortem brain from patients with multiple sclerosis (MS), with an even greater percentage citrullinated in Marburg disease, a more severe form of MS. citMBP isolated from patients with multiple sclerosis (MS) is degraded by cathepsin D at a higher rate than MBP isolated from healthy controls. Cayman's Citrullinated Myelin Basic Protein Polyclonal Antibody can be used for Western blot and ELISA applications. The antibody recognizes citMBP at 21 kDa from human samples, and was generated using a peptide immunogen containing citrullines at R122 and R130 (human myelin basic protein sequence, isoform 5).Synonyms: citMBP, Citrullinated Myelin A1 Protein, Citrullinated Myelin Membrane Encephalitogenic Protein, Myelin A1 Protein, Myelin Membrane Encephalitogenic Protein. Immunogen: Synthetic peptide from the internal region of human myelin basic protein (isoform 5) with citrullines at R122 and R130. MW: 12-18 kDa. Formulation: (Request formulation change), 500 µl of peptide affinity-purified polyclonal antibody. Storage Buffer: PBS, pH 7.2, with 50% glycerol and 0.02% sodium azide. Host: Rabbit. Applications: ELISA and WB. Cross Reactivity: (+) Citrullinated myelin basic protein, (-) Carbamylated proteins, (-) Native myelin basic protein, (-) Other citrullinated proteins. UniProt Accession #: P02686.
Keywords: | Anti-MBP, Anti-MBP, Anti-MBP, Anti-Myelin A1 protein, Anti-Myelin A1 protein, Anti-Myelin basic protein, Anti-Myelin basic protein, Anti-Myelin membrane encephalitogenic protein, Anti-Myelin membrane encephalitogenic protein |
Supplier: | Cayman Chemical |
Supplier-Nr: | 26742 |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide from the internal region of human myelin basic protein (isoform 5) with citrullines at R122 and R130 |
MW: | 12-18 kD |
Format: | Solid |
Database Information
KEGG ID : | K17269 | Matching products |
UniProt ID : | P02686 | Matching products |
Gene ID | GeneID 4155 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed