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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay35904-100 | 100 µl | - | - |
6 - 10 business days* |
480.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The Aurora kinases, Aurora A, -B, and -C, are a family of serine/threonine kinases encoded by... more
Product information "Anti-Aurora A (Phospho-Thr288)/Aurora B (Phospho-Thr232)/Aurora C (Phospho-Thr198) Rabbit Monoclonal"
The Aurora kinases, Aurora A, -B, and -C, are a family of serine/threonine kinases encoded by distinct genes, AURKA, AURKB, and AURKC, respectively, that have roles in mitosis and meiosis. They are composed of an ATP-binding N-terminal domain, a highly conservated catalytic domain, and a short C-terminal domain that contains an activation loop and mediates cofactor binding. Each Aurora kinase contains a key threonine residue in its C-terminal activation loop, threonine 288 (Thr288), Thr232, and Thr198 in Aurora A, -B, and -C, respectively, that is autophosphorylated upon cofactor binding, inducing a conformational change that mediates kinase activation. Aurora A and Aurora B have roles in mitosis, whereas Aurora C regulates meiosis. Aurora A and Aurora B are constitutively expressed in mitotic cells, where Aurora A localizes to the spindle poles and Aurora B localizes to the central spindle. Aurora A has roles in mitotic entry, centrosome maturation and separation, and spindle assembly, whereas Aurora B regulates chromosome condensation and alignment, spindle assembly, and cytokinesis. Aurora C is expressed in germ cells during meiosis, localizes to the chromosome midbody, and is required for spermatogenesis. Aurora A, -B, and -C are overexpressed in a variety of cancers, including breast, colorectal, ovarian, and cervical cancers, and the pan-Aurora kinase inhibitor AMG 900 (Cay-19176) inhibits tumor growth in an HCT116 mouse xenograft model. Cayman's Aurora A (Phospho-Thr288)/Aurora B (Phospho-Thr232)/Aurora C (Phospho-Thr198) Rabbit Monoclonal Antibody (Clone RM454) can be used for immunohistochemistry (IHC) and Western blot (WB) applications.Immunogen: A phospho-peptide corresponding to Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198). Clone Designation: RM454. Formulation: (Request formulation change), 100 µl protein A-affinity purified monoclonal antibody. Storage Buffer: PBS, with 50% glycerol, 1% BSA, and 0.09% sodium azide. Host: Rabbit. Isotype: IgG. Applications: IHC, WB. Cross Reactivity: (+) Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198), (-) Aurora A/Aurora B/Aurora C without phosphorylation at Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198).
Keywords: | Anti-phospho-AIK, Anti-phospho-AURKA, Anti-phospho-hARK1, Anti-phospho-ARK-1, Anti-phospho-Aurora 2, Anti-phospho-Aurora kinase A, Anti-phospho-Aurora-related kinase 1, Anti-phospho-Aurora/IPL1-related kinase 1, Anti-phospho-Breast tumor-amplified kinase |
Supplier: | Cayman Chemical |
Supplier-Nr: | 35904 |
Properties
Application: | IHC, WB |
Antibody Type: | Monoclonal |
Clone: | RM454 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Phospho-peptide corresponding to Phospho-Aurora A (Thr288)/Aurora B (Thr232)/Aurora C (Thr198) |
Format: | Affinity Purified |
Database Information
KEGG ID : | K11481 | Matching products |
UniProt ID : | O14965 | Matching products |
Gene ID | GeneID 6790 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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