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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
BOT-BNUB2250-100 | 100 µl | - |
Request delivery time estimate |
321.00€
|
|||
BOT-BNUB2250-500 | 500 µl | - |
Request delivery time estimate |
693.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Metastasis of a primary tumor to a distant site is determined through signaling cascades that... more
Product information "Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), 0.2mg/mL"
Metastasis of a primary tumor to a distant site is determined through signaling cascades that break down interactions between the cell and extracellular matrix proteins. Among the proteins mediating metastasis are serine proteases, such as neutrophil elastase. Serpins are family of serine protease inhibitors, contain a stretch of peptide that mimics a true substrate for a corresponding serine protease. Serine proteases bind to this substrate mimic in a 1:1 stoichiometric fashion and become catalytically inactive. Aberrant expression of serpin family members can contribute to a number of conditions, including emphysema (-1 antitrypsin deficiency), fatal bleeding (elastase to Thrombin specificity) and thrombosis (antithrombin deficiency), and are indicators of cancer stage phenotypes (circulating levels of squamous cell carcinoma antigen, known as SCCA1, increase in advancing stages of some cervical, lung, esophageal and head and neck cancers). SCCA1 expression has been demonstrated to promote oncogenic transformation and epithelial-mesenchymal transition (EMT) in mammary epithelial cells, and its silencing in breast cancer cells has been shown to halt their proliferation. Primary antibodies are available purified, or with a selection of fluorescent CF(R) Dyes and other labels. CF(R) Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF(R)405S and CF(R)405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors. Concentration: 0.2 mg/mL Storage buffer: PBS, 0.05% BSA, 0.05% azide
Keywords: | Squamous Cell Carcinoma Antigen 1(CPTC-SERPINB3-2), 0.2mg/mL, |
Supplier: | Biotium |
Supplier-Nr: | BNUB2250 |
Properties
Application: | WB (publ.) |
Conjugate: | No |
Format: | Purified, With BSA |
Database Information
Handling & Safety
Storage: | +20°C |
Shipping: | +20°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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