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This gene encodes a zinc finger protein containing five C2H2-type zinc finger domains, one or two Kruppel-associated box A (KRAB A) domains, and a leucine-rich domain. The encoded protein has been suggested to be a transcriptional repressor. It localizes predominantly to the nucleolus. Alternatively spliced transcript variants encoding different isoforms exist. These variants utilize alternative polyadenylation signals. Protein function: Probable transcription repressor. Specifically binds to the 3'-end of zinc-finger coding genes and recruiting chromatin-modifying proteins such as SETDB1 and TRIM28/KAP1, leading to transcription repression. The SETDB1-TRIM28-ZNF274 complex may play a role in recruiting ATRX to the 3'-exons of zinc-finger coding genes with atypical chromatin signatures to establish or maintain/protect H3K9me3 at these transcriptionally active regions (PubMed:27029610). [The UniProt Consortium]
Keywords:
Anti-Zf2, Anti-ZNF274, Anti-SP2114, Anti-ZKSCAN19, Anti-Zinc finger protein 274, Anti-Zinc finger protein zfp2, Anti-Zinc finger protein HFB101, Anti-Neurotrophin receptor-interacting factor homolog, Anti-Zinc finger protein with KRAB and SCAN domains 19,
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