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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG43390.100 | 100 µl | - | - |
6 - 14 business days* |
624.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs,... more
Product information "Anti-YTHDF1"
Protein function: Specifically recognizes and binds N6-methyladenosine (m6A)- containing mRNAs, and promotes mRNA translation efficiency (PubMed:24284625, PubMed:26046440, PubMed:26318451). M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in the efficiency of mRNA splicing, processing and stability (PubMed:24284625). Acts as a regulator of mRNA translation efficiency: promotes ribosome loading to m6A-containing mRNAs and interacts with translation initiation factors eIF3 (EIF3A or EIF3B) to facilitate translation initiation (PubMed:26046440). Required to facilitate learning and memory formation in the hippocampus by enhancing protein synthesis upon neuronal stimulation: in response to neuronal stimulation, binds to m6A-containing neuronal mRNAs, promoting their translation, thereby contributing to learning and memory. Acts as a regulator of axon guidance by binding to m6A- containing ROBO3 transcripts, thereby promoting their translation. Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells. Acts by binding and promoting translation of m6A-containing transcripts encoding proteins involved in lysosomal degradation and phagosome maturation, leading to increased antigen degradation in myeloid dendritic cells. In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation. [The UniProt Consortium]
Keywords: | Anti-DACA-1, Anti-DACA-1, Anti-YTH domain-containing family protein 1, Anti-YTH domain-containing family protein 1, Anti-Dermatomyositis associated with cancer putative autoantigen 1, Anti-Dermatomyositis associated with cancer putative autoantigen 1 |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG43390 |
Properties
Application: | IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, hamster |
Immunogen: | Recombinant protein of Human YTHDF1 |
MW: | 61 kD |
Format: | Affinity Purified |
Database Information
KEGG ID : | K20102 | Matching products |
UniProt ID : | Q9BYJ9 | Matching products |
Gene ID | GeneID 54915 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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