Anti-YTHDC2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA072678.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA072678.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: 3'-5' RNA helicase that plays a key role in the male and female germline by... more

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Product information "Anti-YTHDC2"

Protein function: 3'-5' RNA helicase that plays a key role in the male and female germline by promoting transition from mitotic to meiotic divisions in stem cells (PubMed:26318451, PubMed:29033321). Specifically recognizes and binds N6-methyladenosine (m6A)-containing RNAs, a modification present at internal sites of mRNAs and some non- coding RNAs that plays a role in the efficiency of RNA processing and stability (PubMed:26318451, PubMed:29033321). Essential for ensuring a successful progression of the meiotic program in the germline by regulating the level of m6A-containing RNAs. Acts by binding and promoting degradation of m6A-containing mRNAs: the 3'-5' RNA helicase activity is required for this process and RNA degradation may be mediated by XRN1 exoribonuclease (PubMed:29033321). Required for both spermatogenesis and oogenesis. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 93% and to rat: 76%

Keywords:	Anti-hYTHDC2, Anti-3'-5' RNA helicase YTHDC2, Anti-YTH domain-containing protein 2
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA072678

Properties

Application:	ICC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: TVLNVTDEYD LLDDGGDAVF SQLTEKDVNC LEPWLIKEMD ACLSDIWLHK DIDAFAQVFH LILTENVSVD YRHSETSATA (ATA-APrEST93094)