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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family.... more
Product information "Anti-WWOX"
This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. Protein function: Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development. May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm. [The UniProt Consortium]
Keywords: | Anti-FOR, Anti-WWOX, EC=1.1.1.-, Anti-Fragile site FRA16D oxidoreductase, Anti-WW domain-containing oxidoreductase, Anti-Short chain dehydrogenase/reductase family 41C member 1, WWOX Polyclonal Antibody |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-65947 |
Properties
Application: | IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | Recombinant fusion protein of human WWOX (NP_057457.1). |
Database Information
KEGG ID : | K19329 | Matching products |
UniProt ID : | Q9NZC7 | Matching products |
Gene ID | GeneID 51741 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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