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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
145655.100 | 100 µg | - | - |
3 - 19 business days* |
886.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Wnt10b (also known as Wnt12) is a 4244kD member of the Wnt family of secreted, highly... more
Product information "Anti-Wnt10B (Wnt-10b, Wnt-12)"
Wnt10b (also known as Wnt12) is a 4244kD member of the Wnt family of secreted, highly conserved, cysteinerich glycoproteins that play important roles in vertebrate pattern formation, cell fate decision, axon guidance, and tumor formation (13). Human Wnt10b cDNA encodes a 389 amino acid (aa) precursor that contains a 28 aa signal sequence plus a 361 aa mature protein that contains two glycosylation sites, three potential phosphorylation sites, and a potential palmitoylation site (3, 4). Human Wnt10b shares 9799% aa identity with mouse, rat, equine, porcine, and canine Wnt10b. Wnt10b plays a critical role in maintaining mesenchymal stem cells and determining whether they differentiate to adipocytes or osteoblasts (57). Mouse Wnt10b deletion produces agedependent loss of bone mass due to defective production of osteoblasts, while transgenic overexpression increases postnatal osteoblast differentiation and inhibits adipocyte differentiation (57). Ectopic expression of Wnt10b in an obesity and diabetesprone background, such as the ob/ob mouse, inhibits obesity (8). In mouse skeletal muscle, Wnt10b is expressed inversely with SREBP1c and increases insulin sensitivity (9). In humans, a missense polymorphism is responsible for a malformation of hands and feet, while a C256Y inactivating mutation is associated with severe earlyonset obesity (10, 11). Wnt10b is mainly produced by stem cells and preosteoblasts, but also by adult bone marrow CD8+ T lymphocytes stimulated with parathyroid hormone (12). In some hepatocellular carcinomas, Wnt10b can inhibit cancer cell growth, but in others, it can act synergistically with FGFs to stimulate cell growth (13). Several Wnts, including Wnt10b, are expressed in both normal and/or malignant colon tissues (14). Applications: Suitable for use in ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 825ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: | United States Biological |
Supplier-Nr: | 145655 |
Properties
Application: | ELISA, IHC |
Antibody Type: | Monoclonal |
Clone: | 793116 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Format: | Affinity Purified |
Database Information
UniProt ID : | O00744 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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