Anti-WHSC1L1, CT (Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3,

WHSC1L1 is a histone methyltransferase. This protein preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Applications: Suitable for use in Western Blot, ELISA, Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap., , Note: Applications are based on unconjugated antibody.