Anti-WHSC1L1, CT (Histone-lysine N-methyltransferase NSD3, Nuclear SET domain-containing protein 3,

WHSC1L1 is a histone methyltransferase. This protein preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Applications: Suitable for use in Western Blot, FLISA, Recommended Dilution: FLISA: 1:1,000, Western Blot: 1:100-500, Storage and Stability: Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap., , Note: Applications are based on unconjugated antibody.