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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ7486 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. WD repeat-containing protein 44, also... more
Product information "Anti-WDR44 / RPH11"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. WD repeat-containing protein 44, also called Rabphilin-11 and RPH11, is a protein that in humans is encoded by the WDR44 gene. This gene encodes a protein that interacts with the small GTPase rab11. A similar protein in rat binds the GTP-containing active form of rab11. This protein may play a role in endosome recycling. Alternate splicing results in multiple transcript variants. Protein function: Downstream effector for Rab11 which regulates Rab11 intracellular membrane trafficking functions such as endocytic recycling, intracellular ciliogenesis and protein export (PubMed:31204173, PubMed:32344433). ATK1-mediated phosphorylation of WDR44 induces binding to Rab11 which activates endocytic recycling of transferrin receptor back to the plasma membrane (PubMed:31204173). When bound to Rab11, prevents the formation of the ciliogenic Rab11- Rabin8/RAB3IP-RAB11FIP3 complex, therefore inhibiting preciliary trafficking and ciliogenesis (PubMed:31204173). Participates in neo- synthesized protein export by connecting the endoplasmic reticulum (ER) with the endosomal tubule via direct interactions with the integral ER proteins VAPA or VAPB and the endosomal protein GRAFs (GRAF1/ARHGAP26 or GRAF2/ARHGAP10), which facilitates the transfer of proteins such as E-cadherin, MPP14 and CFTR into a Rab8-Rab10-Rab11-dependent export route (PubMed:32344433). [The UniProt Consortium]
Keywords: | Anti-RPH11, Anti-Rab11BP, Anti-Rabphilin-11, Anti-Rab11-binding protein, Anti-WD repeat-containing protein 44, WDR44 Antibody / RPH11 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ7486 |
Properties
Application: | WB, IHC (paraffin), FC, Direct ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | E. coli-derived recombinant human protein (amino acids D188-S913) |
Format: | Purified |
Database Information
KEGG ID : | K20241 | Matching products |
UniProt ID : | Q5JSH3 | Matching products |
Gene ID | GeneID 54521 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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