Anti-VPS4B

Anti-VPS4B
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-077A-T 10 µl (10 µg) -

3 - 9 business days*

131.00€
A302-077A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway.... more
Product information "Anti-VPS4B"
Protein function: Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). VPS4A/B are required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). [The UniProt Consortium]
Keywords: Anti-SKD1, Anti-MIG1, Anti-VPS4B, EC=3.6.4.6, Anti-Protein SKD1, Anti-Cell migration-inducing gene 1 protein, Anti-Suppressor of K(+) transport growth defect 1, Anti-Vacuolar protein sorting-associated protein 4B
Supplier: Bethyl Laboratories
Supplier-Nr: A302-077A

Properties

Application: IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-077A-T maps to a region between residue 300 and 350 of human vacuolar protein sorting 4 homolog B using the numbering given in entry NP_004860.2 (GeneID 9525).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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