Anti-VEGF165 (human), Azide Free Clone B-G55 [Mouse]

Specificity: Recognises both natural and recombinant human VEGF165, Format: Phosphate-buffered saline. Sterile-filtered through 0.22 µm. Carrier and preservative free, Storage: Stable at +2-8°C for 12 months. For longer storage, freeze aliquots, Application Notes: Suitable for ELISA Protein function: Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin. NRP1/Neuropilin-1 binds isoforms VEGF-165 and VEGF-145. Isoform VEGF165B binds to KDR but does not activate downstream signaling pathways, does not activate angiogenesis and inhibits tumor growth. Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development. [The UniProt Consortium]