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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES12390.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES12390.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes an integral membrane protein that belongs to the... more
Product information "Anti-VAMP8"
This gene encodes an integral membrane protein that belongs to the synaptobrevin/vesicle-associated membrane protein subfamily of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). The encoded protein is involved in the fusion of synaptic vesicles with the presynaptic membrane.[provided by RefSeq, Jun 2010], Protein function: SNAREs, soluble N-ethylmaleimide-sensitive factor-attachment protein receptors, are essential proteins for fusion of cellular membranes. SNAREs localized on opposing membranes assemble to form a trans-SNARE complex, an extended, parallel four alpha-helical bundle that drives membrane fusion. VAMP8 is a SNARE involved in autophagy through the direct control of autophagosome membrane fusion with the lysososome membrane via its interaction with the STX17-SNAP29 binary t- SNARE complex (PubMed:23217709, PubMed:25686604). Also required for dense-granule secretion in platelets (PubMed:12130530). Also plays a role in regulated enzyme secretion in pancreatic acinar cells. Involved in the abscission of the midbody during cell division, which leads to completely separate daughter cells. Involved in the homotypic fusion of early and late endosomes. Participates also in the activation of type I interferon antiviral response through a TRIM6-dependent mechanism (PubMed:31694946). [The UniProt Consortium] Recommended dilutions: IHC-p 1:50-200. Cellular localization: Lysosome membrane , Single-pass type IV membrane protein . Early endosome membrane , Single-pass type IV membrane protein . Late endosome membrane , Single-pass type IV membrane protein . Cell membrane , Single-pass type IV membrane protein . Zymogen granule membrane , Single-pass type IV membrane protein . Perinuclear vesicular structures of the early and late endosomes, coated pits, and trans-Golgi (By similarity). Sub-tight junctional domain in retinal pigment epithelium cells. Midbody region during cytokinesis. Lumenal oriented, apical membranes of nephric tubular cell (By similarity). Cycles through the apical but not through the basolateral plasma membrane (By similarity). Apical region of acinar cells, in zymogen granule membranes (By similarity). .
Keywords: | Anti-EDB, Anti-VAMP-8, Anti-Endobrevin, Anti-Vesicle-associated membrane protein 8, VAMP8 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES12390 |
Properties
Application: | IHC, IF |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthesized peptide derived from human VAMP8 AA range: 46-96 |
Format: | Purified |
Database Information
KEGG ID : | K08512 | Matching products |
UniProt ID : | Q9BV40 | Matching products |
Gene ID | GeneID 8673 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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