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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES5694.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES5694.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
function:Acts as a novel regulator of senescence. Involved in the formation of... more
Product information "Anti-UBN-1"
function:Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly.,similarity:Belongs to the ubinuclein family.,subcellular location:Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.,subunit:Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with Epstein-Barr virus BZLF1. Interacts with HIRA (via WD repeat domain), the interaction is direct. Interacts with ASF1A, CEBPA, TJP1, TJP2 and TJP3.,tissue specificity:Ubiquitous. Also expressed in numerous tumors and cancer cell lines., Protein function: Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication- independent chromatin assembly. [The UniProt Consortium] Recommended dilutions: Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.. Cellular localization: Nucleus, nucleoplasm. Nucleus, PML body. Cell junction, tight junction. Localized as a nuclear speckled-like pattern in proliferating primary fibroblasts. Colocalizes with HIRA, PML and SP100 in PML bodies of senescent cells. Colocalizes with TJP1 and CLDN1. Detected along the upper granular cell layer of epidermis. When overexpressed, accumulates in the nucleus in cells showing defective cytokinesis.
Keywords: | Anti-UBN1, Anti-Protein VT4, Anti-Ubinuclein-1, Anti-HIRA-binding protein, Anti-Ubiquitously expressed nuclear protein, UBN-1 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES5694 |
Properties
Application: | WB, IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse |
Immunogen: | The antiserum was produced against synthesized peptide derived from human Ubinuclein. AA range:161-210 |
Format: | Antiserum |
Database Information
KEGG ID : | K17492 | Matching products |
UniProt ID : | Q9NPG3 | Matching products |
Gene ID | GeneID 29855 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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