Item number Size Datasheet Manual SDS Delivery time Quantity Price
A301-873A-T 20 µl (2 blots) -

3 - 9 business days*

A301-873A-M 100 µl (10 blots) -

3 - 9 business days*

A301-873A 100 µl (20 µg) -

3 - 9 business days*

Protein function: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase... more
Product information "Anti-UBE2O"
Protein function: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). [The UniProt Consortium]
Keywords: Anti-UBE2O, Anti-KIAA1734, Anti-Ubiquitin-protein ligase O, Anti-Ubiquitin carrier protein O, Anti-Ubiquitin-conjugating enzyme E2 O, Anti-Ubiquitin-conjugating enzyme E2-230K, Anti-Ubiquitin-conjugating enzyme E2 of 230 kDa
Supplier: Bethyl Laboratories
Supplier-Nr: A301-873A


Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Bovine, Dog, Horse, Rabbit, Guinea Pig_10141, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, White-tufted-ear Marmoset, Crab-eating Macaque, European Domestic Ferret, African Elephant, Small-eared Galago, Little Brown Bat)
Immunogen: synthetic peptide. The epitope recognized by A301-873A-T maps to a region between residue 725 and 775 of human ubiquitin-conjugating enzyme E2O using the numbering given in entry NP_071349.2 (GeneID 63893).
Format: Antigen Affinity Purified

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