Anti-E2-230K / UBE2O, C-terminal

Anti-E2-230K / UBE2O, C-terminal
Item number Size Datasheet Manual SDS Delivery time Quantity Price
ARG63481.100 100 µg - -

6 - 14 business days*

784.00€
 
Protein function: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase... more
Product information "Anti-E2-230K / UBE2O, C-terminal"
Protein function: E2/E3 hybrid ubiquitin-protein ligase that displays both E2 and E3 ligase activities and mediates monoubiquitination of target proteins (PubMed:23455153, PubMed:24703950). Negatively regulates TRAF6-mediated NF-kappa-B activation independently of its E2 activity (PubMed:23381138). Acts as a positive regulator of BMP7 signaling by mediating monoubiquitination of SMAD6, thereby regulating adipogenesis (PubMed:23455153). Mediates monoubiquitination at different sites of the nuclear localization signal (NLS) of BAP1, leading to cytoplasmic retention of BAP1. Also able to monoubiquitinate the NLS of other chromatin- associated proteins, such as INO80 and CXXC1, affecting their subcellular location (PubMed:24703950). Acts as a regulator of retrograde transport by assisting the TRIM27:MAGEL2 E3 ubiquitin ligase complex to mediate 'Lys-63'-linked ubiquitination of WASH1, leading to promote endosomal F-actin assembly (PubMed:23452853). [The UniProt Consortium]
Keywords: Anti-UBE2O, Anti-KIAA1734, EC=6.3.2.-, EC=6.3.2.19, Anti-Ubiquitin-protein ligase O, Anti-Ubiquitin carrier protein O, Anti-Ubiquitin-conjugating enzyme E2 O, Anti-Ubiquitin-conjugating enzyme E2-230K, Anti-Ubiquitin-conjugating enzyme E2 of 230 kDa
Supplier: Arigo Biolaboratories
Supplier-Nr: ARG63481

Properties

Application: ELISA, IHC (paraffin)
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Species reactivity: human (Expected: mouse, rat, canine, swine, bovine)
Immunogen: ALLEAGMPECTEDK
Format: Ammonium Sulfate Precipitated

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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