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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
T9237-05C.100 | 100 µl | - | - |
3 - 19 business days* |
682.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines... more
Product information "Anti-Tyrosine Hydroxylase (TH, TYH, Tyrosine 3-Hydroxylase, DYT5b, DYT14, Tyrosine 3-Monooxygenase)"
Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine, epinephrine and norepinephrine. Therefore the regulation of the TH enzyme represents the central means for controlling the synthesis of these important catecholamines. FUNCTION: Plays an important role in the physiology of adrenergic neurons. CATALYTIC ACTIVITY: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4a-hydroxytetrahydrobiopterin. COFACTOR: Fe(2+) ion. ENZYME REGULATION: Phosphorylation leads to an increase in the catalytic activity. PATHWAY: Catecholamine biosynthesis, first step. SUBUNIT: Homotetramer. PTM: In vitro, phosphorylation of Ser-19 increases the rate of Ser-40 phosphorylation, which results in enzyme opening and activation. SIMILARITY: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. The presence of different DNA sequences at the TH locus confers susceptibility to various disorders of the brain including manic-depression and schizophrenia. Parkinson's disease is also considered a TH deficiency as low dopamine levels are a consistent neurochemical abnormality. Applications: Suitable for use in Immunohistochemistry and Western Blot. Other applications not tested. , Recommended Dilutions: Immunohistochemistry: 1-2000-1:5000, Western Blot: 1:100-1:500 on RIPA-extracted PC12 cell lysates, Optimal dilutions to be determined by the researcher. Positive Control: Mouse or rat brain containing catecholaminergic neurons (brain stem or striatum). Storage and Stability: Lyophilized and reconstituted products are stable for 12 months after receipt at -20°C. Reconstitute with sterile dH2O. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Supplier: | United States Biological |
Supplier-Nr: | T9237-05C |
Properties
Application: | IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | guinea pig, mouse, rat |
Immunogen: | Synthetic peptide corresponding to aa63-78, PRFIGRRQSLIEDARK to human Tyrosine Hydroxylase (KLH). Homologous to corresponding aa31-47 to TH protein in rat. |
Format: | Serum |
Database Information
KEGG ID : | K00501 | Matching products |
UniProt ID : | P07101 | Matching products |
Gene ID | GeneID 7054 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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