Anti-TSPAN12

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA058244.100	100 µl		-		7 - 10 business days*		446.00€

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Protein function: Regulator of cell surface receptor signal transduction. Plays a central role in... more

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Product information "Anti-TSPAN12"

Protein function: Regulator of cell surface receptor signal transduction. Plays a central role in retinal vascularization by regulating norrin (NDP) signal transduction. Acts in concert with norrin (NDP) to promote FZD4 multimerization and subsequent activation of FZD4, leading to promote accumulation of beta-catenin (CTNNB1) and stimulate LEF/TCF-mediated transcriptional programs. Suprisingly, it only activate the norrin (NDP)-dependent activation of FZD4, while it does not activate the Wnt- dependent activation of FZD4, suggesting the existence of a Wnt- independent signaling that also promote accumulation the beta-catenin (CTNNB1). Acts as a regulator of membrane proteinases such as ADAM10 and MMP14/MT1-MMP. Activates ADAM10-dependent cleavage activity of amyloid precursor protein (APP). Activates MMP14/MT1-MMP- dependent cleavage activity. [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 98% and to rat: 98%

Keywords:	Anti-NET2, Anti-TSPAN12, Anti-Tspan-12, Anti-Tetraspanin-12, Anti-Tetraspan NET-2, Anti-Transmembrane 4 superfamily member 12
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA058244

Properties

Application:	IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: LMVPVQWSDM VTLKARMTNY GLPRYRWLTH AWNFFQREFK CCGVVYFTDW LEMTEMDWPP DSCCVREFPG CSKQAHQEDL SDLYQEGCGK KMY (ATA-APrEST88646)