Anti-TREM1

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Triggering receptor expressed on myeloid cells-1, is encoded by TREM1 gene. Expression is seen is in monocytes and neutrophils but not in lymphocytes, dendritic cells, or other cell types. The expression of Trem1 is upregulated by stimulation with lipopolysaccharide(LPS), gram-negative bacteria, and fungi. Cross-linking of TREM1 on neutrophils induces interleukin-8(IL8) and myeloperoxidase secretion, while cross-linking on monocytes induces not only secretion of IL8 but also of monocyte chemotactic protein-1(MCP1, or SCYA2) and tumor necrosis factor(TNF), MCP1 and TNF secretion could be further upregulated by LPS-mediated priming. Engagement also induces upregulation of adhesion molecules(e.g., ITGB1) and costimulatory molecules(e.g., CD40). TREM1 is associated with DAP12(TYROBP), a molecule frequently associated with activating receptors. Protein function: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. [The UniProt Consortium]