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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-20-1103-50 | 50 µl | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TRIP (TRAF-interacting protei),also known as TRAIP is a component of receptor-TRAF signaling... more
Product information "Anti-TRAIP (TRIP)"
TRIP (TRAF-interacting protei),also known as TRAIP is a component of receptor-TRAF signaling complexes. Structurally it contains an N-terminal RING finger motif and a putative coiled-coil domain and composed of 469 amino acid approximately. TRIP has been shown to associate with TRNFR2 or CD30 signaling complexes through its interaction with TRAF proteins and inhibit TRAF2-mediated NF-kB activation. The recruitment of different TRAFs and TRAF associated proteins like TRIP to receptor complexes can help regulate and provide specificity to the intracellular signals triggered by the cell surface receptors. Protein function: E3 ubiquitin ligase acting as a negative regulator of innate immune signaling. Inhibits activation of NF-kappa-B mediated by TNF. Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920). Involved in response to genotoxic lesions during genome replication. Promotes H2AX and RPA2 phosphorylation after replication-associated DNA damage and assists fork progression at UV-induced replication-blocking lesions during S phase (PubMed:26595769). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys- 63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is controversial (PubMed:26595769). [The UniProt Consortium]
Keywords: | Anti-TRAIP, Anti-RNF206, EC=2.3.2.27, Anti-RING finger protein 206, Anti-TRAF-interacting protein, Anti-E3 ubiquitin-protein ligase TRAIP, Anti-RING-type E3 ubiquitin transferase TRAIP, Polyclonal antibody to TRAIP (TRIP) |
Supplier: | Abeomics |
Supplier-Nr: | 20-1103 |
Properties
Application: | IP, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A synthetic peptide of human TRIP ( amino acids 294-313 ESPAPVEVNLKLRRPSFRDD) was used as immunogen for this antibody |
Format: | Sera |
Database Information
KEGG ID : | K11985 | Matching products |
UniProt ID : | Q9BWF2 | Matching products |
Gene ID | GeneID 10293 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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