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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-20-1102-50 | 50 µl | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human TRAF6 is a 522 amino acid protein. The TRAF (TNF receptor-associated factor) family is a... more
Product information "Anti-TRAF-6"
Human TRAF6 is a 522 amino acid protein. The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases. TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. Protein function: E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as IKBKG, IRAK1, AKT1 and AKT2. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation. Leads to the activation of NF-kappa-B and JUN. May be essential for the formation of functional osteoclasts. Seems to also play a role in dendritic cells (DCs) maturation and/or activation. Represses c- Myb-mediated transactivation, in B-lymphocytes. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation. Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production. [The UniProt Consortium]
Keywords: | Anti-RNF85, Anti-TRAF6, EC=2.3.2.27, Anti-RING finger protein 85, Anti-Interleukin-1 signal transducer, Anti-TNF receptor-associated factor 6, Anti-E3 ubiquitin-protein ligase TRAF6, Anti-RING-type E3 ubiquitin transferase TRAF6, Polyclonal antibody to TR |
Supplier: | Abeomics |
Supplier-Nr: | 20-1102 |
Properties
Application: | IP, IHC, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | rat, mouse, human |
Immunogen: | A synthetic peptide of human TRAF-6 (amino acids 451-469 DAKPELLAFQRPTIPRNPK) was used as immunogen for this antibody |
Format: | Sera |
Database Information
KEGG ID : | K03175 | Matching products |
UniProt ID : | Q9Y4K3 | Matching products |
Gene ID | GeneID 7189 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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