Anti-TRAF-3

This antibody recognizes TRAF3. Human TRAF3 is a member of the, TRAF (TNF Receptor Associated Factor) protein family, having an approximate molecular weight of 568 amino acid.TRAF3 is a CD40 binding protein that contains a RING finger DNA binding motif and Cys/His rich region and coiled COIL domain. Like TRAF1 (TNF Receptor Associated Factor-1) and TRAF2 (TNF Receptor Associated Factor-2), it contains a C-terminal TRAF domain and has an apparent molecular mass of 64 kDa.TRAF3 is involved in mediating the signal transduction of CD40, a TNFR family member important for the activation of the immune response. This protein is found to be a critical component of the, LtBetaR (Lymphotoxin-Beta Receptor) signaling complex, which induces NF-KappaB activation and cell death initiated by LT-Beta (Lymphotoxin-Beta) ligation. Protein function: Regulates pathways leading to the activation of NF- kappa-B and MAP kinases, and plays a central role in the regulation of B-cell survival. Part of signaling pathways leading to the production of cytokines and interferon. Required for normal antibody isotype switching from IgM to IgG. Plays a role T-cell dependent immune responses. Plays a role in the regulation of antiviral responses. Is an essential constituent of several E3 ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein ligase activity and promote 'Lys-63'-linked ubiquitination of target proteins. Inhibits activation of NF-kappa-B in response to LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa- B. Down-regulates proteolytic processing of NFKB2, and thereby inhibits non-canonical activation of NF-kappa-B. Promotes ubiquitination and proteasomal degradation of MAP3K14. [The UniProt Consortium]