Anti-TPX2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A300-429A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A300-429A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: Spindle assembly factor required for normal assembly of mitotic spindles.... more

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Product information "Anti-TPX2"

Protein function: Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules (PubMed:18663142, PubMed:19208764). Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation (PubMed:18663142, PubMed:19208764). TPX2 is inactivated upon binding to importin- alpha (PubMed:26165940). At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation (PubMed:26165940). [The UniProt Consortium]

Keywords:	Anti-p100, Anti-TPX2, Anti-DIL-2, Anti-C20orf1, Anti-Protein fls353, Anti-Targeting protein for Xklp2, Anti-Hepatocellular carcinoma-associated antigen 90, Anti-Hepatocellular carcinoma-associated antigen 519
Supplier:	Bethyl Laboratories
Supplier-Nr:	A300-429A

Properties

Application:	WB, IP, ICC-IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: chimpanzee, northern white-cheeked gibbon)
Immunogen:	synthetic peptide. The epitope recognized by A300-429A-T maps to a region between residues 150 and 200 of human TPX2 using the numbering given in Swiss-Prot entry Q9ULW0 (GeneID 22974).
Format:	Antigen Affinity Purified