Anti-TOPBP1

Item number	Size	Manual	Delivery time	Price
E-AB-67704.60	60 µl	-	7 - 16 business days*	198.00€
E-AB-67704.120	120 µl	-	7 - 16 business days*	317.00€
E-AB-67704.200	200 µl	-	7 - 16 business days*	525.00€

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This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase... more

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Product information "Anti-TOPBP1"

This gene encodes a binding protein which interacts with the C-terminal region of topoisomerase II beta. This interaction suggests a supportive role for this protein in the catalytic reactions of topoisomerase II beta through transient breakages of DNA strands. Protein function: Required for DNA replication. Plays a role in the rescue of stalled replication forks and checkpoint control. Binds double-stranded DNA breaks and nicks as well as single-stranded DNA. Recruits the SWI/SNF chromatin remodeling complex to E2F1-responsive promoters. Down-regulates E2F1 activity and inhibits E2F1-dependent apoptosis during G1/S transition and after DNA damage. Induces a large increase in the kinase activity of ATR (PubMed:16530042). [The UniProt Consortium]

Keywords:	Anti-TopBP1, Anti-TOPBP1, Anti-KIAA0259, Anti-DNA topoisomerase 2-binding protein 1, Anti-DNA topoisomerase II-binding protein 1, Anti-DNA topoisomerase II-beta-binding protein 1, TOPBP1 Polyclonal Antibody
Supplier:	Elabscience
Supplier-Nr:	E-AB-67704

Properties

Application:	WB, IHC, IF
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Recombinant fusion protein of human TOPBP1 (NP_008958.2).