Anti-Toll-like receptor 5 / Tlr5

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. Predicted to enable interleukin-1 receptor binding activity and signaling receptor activity. Predicted to be involved in several processes, including positive regulation of interleukin-8 production, positive regulation of nitric oxide biosynthetic process, and positive regulation of toll-like receptor signaling pathway. Predicted to act upstream of or within innate immune response. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in brain, olfactory epithelium, spinal cord, and trunk unsegmented mesenchyme. Human ortholog(s) of this gene implicated in Legionnaires' disease, cystic fibrosis, cystitis, melioidosis, and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5). Protein function: Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF- kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life. [The UniProt Consortium]