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The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain, a transmembrane domain, and a truncated cytoplamic death domain. This receptor does not induce apoptosis, and has been shown to play an inhibitory role in TRAIL-induced cell apoptosis. Protein function: Receptor for the cytotoxic ligand TRAIL. Contains a truncated death domain and hence is not capable of inducing apoptosis but protects against TRAIL-mediated apoptosis. Reports are contradictory with regards to its ability to induce the NF- kappa-B pathway. According to PubMed:9382840, it cannot but according to PubMed:9430226, it can induce the NF-kappa-B pathway. [The UniProt Consortium]
Keywords:
Anti-DCR2, Anti-DcR2, Anti-CD264, Anti-TRAIL-R4, Anti-TNFRSF10D, Anti-Decoy receptor 2, Anti-TRAIL receptor 4, Anti-TRAIL receptor with a truncated death domain, Anti-TNF-related apoptosis-inducing ligand receptor 4, TNFRSF10D Polyclonal Antibody
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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