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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-20T-0301R-C100 | 100 µg | - |
3 - 9 business days* |
479.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a... more
Product information "Anti-TLR3 (human), clone ABM15D5 (R-PE)"
TLR3 (Toll-like Receptor 3) is a member of the TLR (Toll-like receptor) family that plays a fundamental role in pathogen recognition and activation of innate immunity. TLR3 consist of pathogen-binding ECDs (Ectodomains) and cytoplasmic signaling domains, known as TIR (Toll IL-1 Receptor) domains, joined by a single transmembrane helix. TLR3 is a nucleotide-sensing TLR, activated by double-stranded RNA (dsRNA) which is associated with viral infection. Additional to dsRNA it binds also to synthetic ligands mimicking dsRNA (such as Poly I:C). It acts via the adapter TRIF/TICAM1 and induces the activation of IRF3, ultimately inducing the production of type I interferons (IFNs). It has been demonstrated extensively that TLR3 activation leads to cross-priming of CD8+ T cells via major histocompatibility complex I for the generation of cytotoxic T cell (CTL) responses. TLR3 displays a protective role in mouse models of atherosclerosis and against brain ischemia. Protein function: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response. [The UniProt Consortium]
Keywords: | Anti-TLR3, Anti-CD283, Anti-Toll-like receptor 3 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20T-0301R |
Properties
Antibody Type: | Monoclonal |
Clone: | ABM15D5 |
Conjugate: | Phycoerythrin |
Database Information
KEGG ID : | K05401 | Matching products |
UniProt ID : | O15455 | Matching products |
Gene ID | GeneID 7098 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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