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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ7456 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. T-cell immunoglobulin and mucin domain... more
Product information "Anti-TIMD4 / T-cell immunoglobulin mucin receptor 4"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene. Protein function: Phosphatidylserine receptor that plays different role in immune response including phagocytosis of apoptotic cells and T-cell regulation. Controls T-cell activation in a bimodal fashion, decreasing the activation of naive T-cells by inducing cell cycle arrest, while increasing proliferation of activated T-cells by activating AKT1 and ERK1/2 phosphorylations and subsequent signaling pathways. Also plays a role in efferocytosis which is the process by which apoptotic cells are removed by phagocytic cells (PubMed:32703939, PubMed:34067457). Mechanistically, promotes the engulfment of apoptotic cells or exogenous particles by securing them to phagocytes through direct binding to phosphatidylserine present on apoptotic cells, while other engulfment receptors such as MERTK efficiently recognize apoptotic cells and mediate their ingestion (PubMed:32640697). Additionally, promotes autophagy process by suppressing NLRP3 inflammasome activity via activation of LKB1/PRKAA1 pathway in a phosphatidylserine-dependent mechanism. [The UniProt Consortium]
Keywords: | Anti-TIM4, Anti-TIM-4, Anti-TIMD4, Anti-TIMD-4, Anti-T-cell membrane protein 4, Anti-T-cell immunoglobulin mucin receptor 4, Anti-T-cell immunoglobulin and mucin domain-containing protein 4, TIMD4 Antibody / T-cell immunoglobulin mucin receptor 4 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ7456 |
Properties
Application: | WB, Direct ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | E. coli-derived recombinant human protein (amino acids S24-L378) |
Format: | Purified |
Database Information
KEGG ID : | K26936 | Matching products |
UniProt ID : | Q96H15 | Matching products |
Gene ID | GeneID 91937 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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