Anti-TIF1 gamma / TRIM33, clone 3H7-C8-B9

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG54025.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear... more

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Product information "Anti-TIF1 gamma / TRIM33, clone 3H7-C8-B9"

Protein function: Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2/3 resulting in inhibition of TGF- beta/BMP signaling cascade). [The UniProt Consortium]

Keywords:	Anti-TRIM33, Anti-KIAA1113, EC=6.3.2.-, Anti-TIF1-gamma, Anti-Protein Rfg7, Anti-Ectodermin homolog, Anti-RET-fused gene 7 protein, Anti-E3 ubiquitin-protein ligase TRIM33, Anti-Tripartite motif-containing protein 33
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG54025

Properties

Application:	WB
Antibody Type:	Monoclonal
Clone:	3H7-C8-B9
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Purified recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E.coli
Format:	Affinity Purified