Anti-TIF1 alpha / TIF1A / TRIM24, clone 4G6C2

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ7128 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tripartite motif-containing 24 (TRIM24)... more
Product information "Anti-TIF1 alpha / TIF1A / TRIM24, clone 4G6C2"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Tripartite motif-containing 24 (TRIM24) also known as transcriptional intermediary factor 1a (TIF1a) is a protein that, in humans, is encoded by the TRIM24 gene. The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear receptors, including the estrogen, retinoic acid, and vitamin D3 receptors. The protein localizes to nuclear bodies and is thought to associate with chromatin and heterochromatin-associated factors. The protein is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene. Protein function: Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. During the DNA damage response, participates in an autoregulatory feedback loop with TP53. Early in response to DNA damage, ATM kinase phosphorylates TRIM24 leading to its ubiquitination and degradation. After sufficient DNA repair has occurred, TP53 activates TRIM24 transcription, ultimately leading to TRIM24-mediated TP53 ubiquitination and degradation (PubMed:24820418). Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up- regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes. Participates also in innate immunity by mediating the specific 'Lys-63'-linked ubiquitination of TRAF3 leading to activation of downstream signal transduction of the type I IFN pathway (PubMed:32324863). Additionally, negatively regulates NLRP3/CASP1/IL- 1beta-mediated pyroptosis and cell migration probably by ubiquitinating NLRP3 (PubMed:33724611). [The UniProt Consortium]
Keywords: Anti-RNF82, Anti-TRIM24, Anti-TIF1-alpha, Anti-RING finger protein 82, Anti-E3 ubiquitin-protein ligase TRIM24, Anti-Tripartite motif-containing protein 24, Anti-Transcription intermediary factor 1-alpha, Anti-RING-type E3 ubiquitin transferase TIF1-alpha
Supplier: NSJ Bioreagents
Supplier-Nr: RQ7128

Properties

Application: WB, IHC (paraffin), IF
Antibody Type: Monoclonal
Clone: 4G6C2
Conjugate: No
Host: Mouse
Species reactivity: human
Immunogen: Recombinant human TRIM24 protein (amino acids A706-D964)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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