Anti-TCF7L2

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG41987.100	100 µl		-	-	6 - 14 business days*		624.00€

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Protein function: Participates in the Wnt signaling pathway and modulates MYC expression by... more

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Product information "Anti-TCF7L2"

Protein function: Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. [The UniProt Consortium]

Keywords:	Anti-TCF4, Anti-TCF-4, Anti-hTCF-4, Anti-TCF7L2, Anti-T-cell factor 4, Anti-Transcription factor 7-like 2, Anti-HMG box transcription factor 4, Anti-T-cell-specific transcription factor 4
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG41987

Properties

Application:	FC, ICC, IF, IHC (paraffin), IP, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Synthetic peptide of Human TCF7L2
MW:	68 kD
Format:	Affinity Purified