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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-R30610 | 100 µg | - | - |
3 - 10 business days* |
755.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.5mg/ml if reconstituted with 0.2ml sterile DI water. TATA-binding protein is a general... more
Product information "Anti-TBP TATA Binding Protein"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. TATA-binding protein is a general transcription factor that binds specifically to a DNA sequence called the TATA box. The gene is mapped to 6q27. This DNA sequence is found about 35 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex. As one of the few proteins in the preinitiation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably only one of the proteins involved in positioning RNA polymerase II. Protein function: General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre- initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II. Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1 with the rDNA promoter. SL1 is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. [The UniProt Consortium]
Keywords: | Anti-TBP, Anti-GTF2D1, Anti-TATA-box factor, Anti-TATA-binding factor, Anti-TATA-box-binding protein, Anti-TATA sequence-binding protein, Anti-Transcription initiation factor TFIID TBP subunit, TBP Antibody TATA Binding Protein |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | R30610 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | An amino acid sequence from the middle region of human TATA binding protein (EEQSRLAARKYARVVQKLGF) was used as the immunogen for this TBP antibody (100% homologous in human, mouse and rat). |
Format: | Purified |
Database Information
KEGG ID : | K03120 | Matching products |
UniProt ID : | P20226 | Matching products |
Gene ID | GeneID 6908 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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