Anti-Syndecan 2

Syndecans are cell surface heparan sulfate proteoglycans that act as co-receptors for growth factor binding, cell-matrix interactions, and cell-cell interactions to regulate cell adhesion, proliferation, and differentiation. Syndecan-2 interacts with matrix proteins such as laminin and fibronectin, and its cytoplasmic V region controls matrix assembly at the cell surface. Syndecan-2 is essential for angiogenic sprouting during embryogenesis and controls the growth of normal human osteoblastic cells. Syndecan-2 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. Altered syndecan-2 expression has been detected in several different tumor types. Applications: Suitable for use in Direct ELISA and Immunohistochemistry. Other applications not tested. Recommended Dilution: Immunohistochemistry: 8-25ug/ml Detects Syndecan-2 in paraffin-embedded normal human skin tissue sections., Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.