Anti-SuFu

Anti-SuFu
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-335A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-335A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-335A 100 µl (20 µg) -

3 - 9 business days*

465.00€
 
Protein function: Negative regulator in the hedgehog signaling pathway. Down-regulates... more
Product information "Anti-SuFu"
Protein function: Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes (PubMed:15367681, PubMed:24311597, PubMed:24217340). Down- regulates GLI2-mediated transactivation of target genes (PubMed:24311597, PubMed:24217340). Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein (PubMed:10806483, PubMed:24217340). Negative regulator of beta- catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A). Required for normal embryonic development. Required for the proper formation of hair follicles and the control of epidermal differentiation. [The UniProt Consortium]
Keywords: Anti-SUFU, Anti-SUFUH, Anti-Suppressor of fused homolog
Supplier: Bethyl Laboratories
Supplier-Nr: A302-335A

Properties

Application: WB, IP
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Rat, Dog, Horse, Rabbit, Guinea Pig_10141, Pig, Panda, Orangutan, Rhesus Monkey, Gorilla, Chimpanzee, Tasmanian Devil, White-tufted-ear Marmoset, Crab-eating Macaque, African Elephant, Northern White-cheeked Gibbon)
Immunogen: synthetic peptide. The epitope recognized by A302-335A-T maps to a region between residue 434 and 484 of human suppressor of fused homolog using the numbering given in entry NP_057253.2 (GeneID 51684).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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