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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES3466.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES3466.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
SMG7, nonsense mediated mRNA decay factor(SMG7) Homo sapiens This gene encodes a protein that is... more
Product information "Anti-SMG7"
SMG7, nonsense mediated mRNA decay factor(SMG7) Homo sapiens This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD), a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011], Protein function: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Cytoplasm . Nucleus . Predominantly cytoplasmic, and nuclear. Shuttles between nucleus and cytoplasm. .
Keywords: | Anti-hSMG-7, Anti-SMG-7 homolog, Anti-Nonsense-mediated mRNA decay factor SMG7, SMG7 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES3466 |
Properties
Application: | WB, IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, rat, mouse, |
Immunogen: | The antiserum was produced against synthesized peptide derived from human SMG7. AA range:521-570 |
MW: | 127 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K14409 | Matching products |
UniProt ID : | Q92540 | Matching products |
Gene ID | GeneID 9887 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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