Anti-Smac / diablo

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG54330.50	50 µg		-	-	6 - 14 business days*		608.00€

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Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9... more

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Product information "Anti-Smac / diablo"

Protein function: Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. [The UniProt Consortium]

Keywords:	Anti-SMAC, Anti-Smac, Anti-DIABLO, Anti-Diablo homolog, mitochondrial, Anti-Direct IAP-binding protein with low pI, Anti-Second mitochondria-derived activator of caspase
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG54330

Properties

Application:	WB, IHC
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human
Immunogen:	Synthetic peptide corresponding to aa 225-239 of human Smac (accession no. AAF87716)
Format:	Affinity Purified